Chronic kidney disease (CKD) is a major global health issue – affecting an estimated 1 in 10 people – yet it is frequently overlooked on health agendas worldwide. In its early stages, CKD is often asymptomatic, and many individuals are unaware that they have CKD until the disease has progressed to later stages, where it becomes harder and more costly to treat – with patients facing the prospect of dialysis or kidney transplant. This makes early CKD detection critical to improving patient outcomes and reducing the growing health and economic burden of CKD worldwide. Recognising this, the World Kidney Day campaign this year is centred around the theme: “Detect early, protect kidney health.”
Addressing growing rates of obesity and its increasing strain on healthcare systems has become a key focus for many public health strategies around the globe. As part of the evolving landscape of obesity interventions, GLP-1 receptor agonists (commonly referred to as GLP-1 agonists) have emerged as a promising pharmacological solution. But how effective are GLP-1 agonists as part of a broader public health obesity strategy?
When the Covid-19 pandemic hit in early 2020, drinking habits shifted significantly for many. But what happens when those pandemic-era drinking habits stick around? Recent research from HealthLumen explores the long-term consequences of changes in alcohol consumption during the pandemic, and the findings are stark: if those patterns continue until the end of 2035, England could face nearly 10,000 additional premature deaths, over 147,000 excess cases of disease, and £1.2 billion extra in healthcare costs.
Earlier diagnosis can make all the difference for individuals with genetic diseases. Delayed diagnosis hinders timely disease management and treatment access, meaning that progression to late-stage disease can occur more rapidly, likely leading to a significant increase in the health and economic burden of these conditions for patients, their families, and healthcare systems. Screening programs aim to identify individuals with genetic conditions earlier, with cascade screening in particular providing one way to help transform outcomes for patients.
As part of AstraZeneca’s Accelerate Change Together (ACT) on CKD programme to drive chronic kidney disease (CKD) change across the healthcare ecosystem, the Inside CKD project stream projected the clinical and economic burden of CKD from 2022 to 2027 across 31 countries and regions. The results have recently been compiled into a comprehensive portal on the Inside CKD website.
“Genomics requires a form of modelling that can capture individual genetic differences and responses to therapy – a purpose to which microsimulation is eminently suited.”
This quote, from a seminal review paper by Professors Deborah Schofield and Rupendra Shrestha of Macquarie University, pioneers in applying microsimulation techniques for modelling the costs and benefits of genomic medicine, formed the basis for a fascinating recent discussion with the HealthLumen team, on the role of microsimulation modelling techniques in precision medicine.
Non-communicable diseases (NCDs), including heart disease, stroke, cancer, diabetes and chronic lung disease, are the leading causes of death worldwide. A recent report by FP Analytics sets out the scale of the problem and the health and economic burden of NCDs. These conditions share a common set of risk factors of which the main ones […]
Of the three main phases of clinical trials, by far the most expensive part of the process is the Phase 3 trial, typically requiring from several hundred to several thousand participants and costing up to $20 million on average. Furthermore, the process is fraught with risks with up to 70% of Phase 2 trials and […]
We’re pleased to share the latest in our series of posts from our interns. Daniel Ohrenstein has just completed an extended 5-month stay with us working on some exciting new techniques for multiple risk factor modelling. Daniel Ohrenstein I recently completed an MSc in Machine Learning and Data Science at UCL, having graduated with a […]
As we move into the autumn, we’re pleased to share the last in our series of posts from some of our first summer interns. Annie Estlin I recently graduated from the University of Cambridge with an MPhil in Epidemiology. It’s been incredibly exciting to work for HealthLumen this summer and apply my learning in the […]
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